Phase I/II Trial of Sorafenib in Combination with Vinorelbine as First-Line Chemotherapy for Metastatic Breast Cancer.

There was a marginal significance for an increase of the area under the curve until the last measurable concentration (AUClast) of sorafenib in the presence of vinorelbine.

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We believe that part of these findings derive from the significant pharmacokinetic interaction between sorafenib and vinorelbine that we observed, resulting in a marginally significant increase of AUClast of sorafenib and more importantly a statistically significant increase in Cmax of vinorelbine when the two drugs are combined.

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