Barely Significant
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Beyond metformin: safety considerations in the decision-making process for selecting a second medication for type 2 diabetes management: reflections from a diabetes care editors' expert forum.

Diabetes Care · 2014 · PMC5169170 · PMID 25147257

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possibly significantno p-value reported
Although the most frequent adverse effects—genital mycotic and urinary tract infections—appear to be more an issue of patient tolerance than of safety, we await more data regarding possibly significant metabolic and other side effects, as well as further elucidation of potential cancer risks.

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