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Efficacy and safety of thrombopoietin receptor agonists in patients with primary immune thrombocytopenia: A systematic review and meta-analysis.

Sci Rep · 2016 · PMC5171907 · PMID 27991534

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an increasing trendno p-value reported
Second, close monitoring of hepatobiliary laboratory test results is recommended during eltrombopag treatment due to an increasing trend in the incidence of liver function abnormalities among ITP patients receiving this treatment.

also in 63,971 other papers

a decreasing trendno p-value reported
The incidence of AEs in the TPO-RA-treated groups was similar to that in the placebo groups, and there was a decreasing trend in the incidence of severe AEs in ITP patients receiving TPO-RAs compared with control subjects.

also in 47,180 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.