Presence of TMPRSS2-ERG is associated with alterations of the metabolic profile in human prostate cancer.

The in vivo citrate/creatine ratio from spatially matched voxels was decreased with borderline significance in ERG high compared to ERG low , p = 0.083 (Figure 5A ), while choline/creatine and spermine/creatine ratios were not significant, p = 0.667 and p = 0.158, respectively (Figure 5B ).

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However, a highly significant increased expression of oxoglutarate dehydrogenase-like ( OGDHL ), a key control point in the TCA, was found in ERG high compared to ERG low .

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However, no significant difference in biochemical recurrence was detected, although a trend towards significance was detected for low Gleason samples.

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