not quite significantP < 0.01
Although the interaction was not quite significant [F(2,21) = 2.75] Bonferroni post-hoc test revealed a significant increase in ME7 + TNF-α at 2 h when compared with NBH + TNF-α at 2 h (P < 0.01) ( Fig.3 d). 3.3 TNF-α induces an exaggerated sickness response in ME7 animals The data on CNS cytokines and RANKL predicted differential effects of systemic TNF-α (250 μg/kg) on sickness parameters in NBH and ME7 animals.