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An Intranasal Proteosome-Adjuvanted Trivalent Influenza Vaccine Is Safe, Immunogenic & Efficacious in the Human Viral Influenza Challenge Model. Serum IgG & Mucosal IgA Are Important Correlates of Protection against Illness Associated with Infection.

PLoS One · 2016 · PMC5179046 · PMID 28005959

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a slight trendno p-value reported
There was no apparent worsening of findings following the second dose and a slight trend toward reduced subject reported reactogenicity.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.