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Estrogenic Endocrine Disrupting Chemicals Influencing NRF1 Regulated Gene Networks in the Development of Complex Human Brain Diseases.

Int J Mol Sci · 2016 · PMC5187886 · PMID 27983596

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an increasing trendno p-value reported
There is only one study in which human brain levels of estrogens have been measured; and these hormones do not change significantly with age in postmenopausal women, rather estradiol (E2) showed an increasing trend from age 60–100 years [ 257 ].

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