Polymorphism of the Transcription Factor 7-Like 2 Gene (TCF7L2) Interacts with Obesity on Type-2 Diabetes in the PREDIMED Study Emphasizing the Heterogeneity of Genetic Variants in Type-2 Diabetes Risk Prediction: Time for Obesity-Specific Genetic Risk Scores.

Nutrients · 2016 · PMC5188448 · PMID 27929407

Europe PMC DOI

hedged sentences

0.0550

closest p · 1.1× alpha

0.0550

boldest claim

The sentences

borderline significantp = 0.055so close (0.05 < p ≤ 0.1)

For some of these SNPs (in the ZFAND6, ADYC5, IGF2BP2, SLC30A8, KLHDC5, and HMGA2 genes), statistically significant or borderline significant interactions with BMI (or with waist circumference) in determining T2D were reported in the EPIC-InterAct study ( p = 0.055, p < 0.01; p = 0.034; p = 0.099; p = 0.10, respectively) [ 16 ].

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near significanceno p-value reported

Those SNPs showing significant (or near significance) associations in one of the obesity strata were selected for combination in the corresponding obesity-specific GRS (nobGRS and obGRS).

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