Pharmacokinetics of the Antiviral Lectin Griffithsin Administered by Different Routes Indicates Multiple Potential Uses.

After subcutaneous administration of 10 mg/kg GRFT, these pharmacokinetic parameters showed an increasing trend: 1.3 ± 0.3 h, 2.1 ± 0.9 h, and 13.8 ± 6.8 h were obtained as absorption, distribution, and elimination half-lives, respectively; similar values were obtained with the high dose of 20 mg/kg for these parameters.

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This was followed by a decreasing trend, similar to that observed in intravenously dosed animals.

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