Distinct roles of immunoreceptor tyrosine-based motifs in immunosuppressive indoleamine 2,3-dioxygenase 1.

Interestingly, on measuring the fold change in β‐tubulin‐normalized IDO1 expression at 180 min., we found a highly significant decrease ( P < 0.001), particularly in the expression of the Y253E mutant – mimicking tyrosine phosphorylation in ITIM2 – relative to WT IDO1.

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