Application of Mice Humanized for CYP2D6 to the Study of Tamoxifen Metabolism and Drug-Drug Interaction with Antidepressants.

Drug Metab Dispos · 2017 · PMC5193068 · PMID 27756789

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However, pretreatment with paroxetine resulted in decreased exposure to endoxifen, with a highly significant reduction in the area under the curve (AUC all ) and a moderate but nonsignificant decrease in C max ( Fig. 4B ; Table 2 ).

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