Quantitative Assessment of Population Variability in Hepatic Drug Metabolism Using a Perfused Three-Dimensional Human Liver Microphysiological System.

J Pharmacol Exp Ther · 2017 · PMC5193075 · PMID 27760784

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a nonsignificant trendno p-value reported

However, for the majority of genes in the liver MPS, there was a nonsignificant trend that the pooled hepatocytes marginally overpredict the average mRNA expression obtained across the different donors, whereas for the majority of genes in the freshly thawed hepatocytes, the opposite nonsignificant trend was observed ( Supplemental Fig.

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an overall trendno p-value reported

Urea production also exhibited an overall trend of increase at postdose measurements for all treatments, except prednisolone.

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