Stress and multiple sclerosis: A systematic review considering potential moderating and mediating factors and methods of assessing stress.

(1998) observed a nonsignificant trend toward more stressful events in MS patients than in patients with polyneuropathy (24.6% vs. 14.8%) in the year before onset.

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Some studies report an association between stress and MS ( Buljevac et al., 2003 ; Mohr et al., 2000 ; Warren et al., 1982 ) but others failed to find this association or only found a quasi-significant relationship ( Gasperini et al., 1995 ; Riise et al., 2011 ).

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