Cognitive decline in the elderly after surgery and anaesthesia: results from the Oxford Project to Investigate Memory and Ageing (OPTIMA) cohort.

Interestingly, the borderline significance of the positive co‐efficient β 9 for the interaction term S2.(t − T2) indicates that second surgery may slow the rate of decline in CAMCOG score to a similar extent to which it had been worsened by first surgery (p = 0.05).

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The highly significant co‐efficient β 13 associated with variable D.S1(t − T1) suggests that it is those patients with a diagnosis who are susceptible to the effects of first surgery; for the cohort as a whole, the non‐significant co‐efficient β 8 for the variable S1.(t − T1) indicates that individuals without a diagnosis may be exempted from the risk of surgery.

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