Besides revealing (patho) physiological settings for Fundc1 -mediated mitophagy, this work is also highly significant from the translational point of views: The authors show that platelet-specific KO of Fundc1 or Atg5 reduces I/R injury and protects heart function in a mouse model of myocardial infarction.
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Hypoxic mitophagy regulates mitochondrial quality and platelet activation and determines severity of I/R heart injury.
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