Identification of genetic modifiers of age-at-onset for familial Parkinson's disease.

Similarly, TPM1 rs117267308 was not associated with age-at-onset in non-familial PD in GWAS (Cox P = 1.00, β = 0.02 years) and had only a weak trend in replication (Cox with Firth correction P = 0.02, β = ‐1.80 years), which may be due to misclassification of some familial cases as non-familial due to the difficulty in recall and knowledge of family members.

also in 1,404 other papers

The replication signals for 8q23.3 and 14q21.3 were borderline significant and when combined with NGRC, the signals were less significant than NGRC alone ( Table 2 ).

also in 11,409 other papers