highly significantp=0.002
In this case oxysterol metabolising enzyme signature was highly significant in both the whole patient cohort (p=0.002, HR=1.791, 95% CI 1.236-2.595) and the mismatch repair proficient group (p=0.011, HR=1.703, 95% CI, 1.129-2.568) ( Supplementary Table 9 ).