Loss of T-cell quiescence by targeting Slfn2 prevents the development and progression of T-ALL.

In addition, in a mixed BM chimera setting in which irradiated mice were transplanted with a mixture (1:1 ratio) of ICN1 retrovirus transduced wild-type (CD45.1) and elektra (CD45.2) BM cells (Figure 2b ), a highly significant overtake of wild-type origin immature double positive and double negative T-cells was observed in the blood already 4 weeks after transplantation (Figure 2c ) and in the BM, thymus, lungs, lymph nodes and spleen 7 weeks after transplantation (Figure 2e ).

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