A pig model of acute right ventricular afterload increase by hypoxic pulmonary vasoconstriction.

(In the one animal with a baseline mPAP above 25 mmHg, the FiO 2 was lowered to 0.15.) This yielded a highly significant overall increase in mPAP from 18.3 (4.2) to 28.4 (4.6) mmHg (p ≪ 0.0001) (Table 1 ).

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