Barely Significant
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Large Preferred Region for Packaging of Bacterial DNA by phiC725A, a Novel Pseudomonas aeruginosa F116-Like Bacteriophage.

PLoS One · 2017 · PMC5217972 · PMID 28060939

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The sentences

highly significantp-value < 2.2e-16actually significant
These differences are highly significant (X 2 test p-value < 2.2e-16).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.