A gene expression inflammatory signature specifically predicts multiple myeloma evolution and patients survival.

We found 10 genes (IL15, IL17A, EBI3, CCL3, CCL5, LTB, CSF2, IFNG, RANKl and NOS2) with highly significant differential expression ( P <0.01), 6 genes (IL2, IL8, IL10, TNF, TGFB1 and VEGFA) with significant differential expression ( P <0.05 but >0.01) and 5 genes (IL6, IL12A, CCL2, LTA) not correlated with the disease status according to Kruskal–Wallis ANOVA test ( Table 1 ).

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