highly significantP = 2.2× 10 −16
In addition, the correlation between gene expression and TF binding was highly significant ( P = 2.2× 10 −16 , see Additional file 1 Supplementary Methods) and the likelihood of a TF complex near transcriptionally active genes showed that the TF complexes are most likely located -1kbp to 0.5kbp around TSS (Fig.