Mechanisms of Accelerated Liver Fibrosis Progression during HIV Infection.

Introduction Liver disease is a major cause of morbidity and the main cause of mortality, independent of acquired immunodeficiency syndrome (AIDS), in persons infected with the human immunodeficiency virus (HIV), with liver fibrosis being a highly significant contributor. 1 Although HIV co-infection with hepatitis B virus (HBV) or hepatitis C virus (HCV) is frequent, there is mounting evidence of an increased risk in liver-related morbidity and mortality in the absence of viral hepatitis. 2 , 3 Cross-sectional studies using liver stiffness measurement (

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