Mutant HSPB1 causes loss of translational repression by binding to PCBP1, an RNA binding protein with a possible role in neurodegenerative disease.

The correlation between RT-qPCR and RNA sequencing data for 50 additional genes (Additional file 2 : Table S1) was highly significant (Pearson’s correlation coefficient = 0,641; Fig. 4d ), indicating that the RNA sequencing data are robust and reliable.

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