Prophylactic orthosteric inhibition of leukocyte integrin CD11b/CD18 prevents long-term fibrotic kidney failure in cynomolgus monkeys.

Kidney function in four additional pairs of monkeys To assess the significance of the above findings in a larger cohort and the longer-term effects of preemptive mAb107 treatment on the right kidney function following I/R, the above studies were repeated in eight additional monkeys, randomized to four in each group, a number expected to yield highly significant ( P ≤0.2) differences based on the initial pair.

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