Synthetic and natural antioxidants attenuate cisplatin-induced vomiting.

Highly significant reductions in the number of bouts were found with MPG [ F (3,28) = 10.62, P < 0.0001] (10, 20 mg/kg; 0–8 h, P < 0.001) (Fig. 2a ), Vit-C [ F (3,28) = 9.985, P = 0.0001] (100–300 mg/kg; 0–4 h, P < 0.001) (Fig. 2b ), GP [ F (3,28) = 50.97, P < 0.0001] (50–150 mg/kg; 0–8 h, P < 0.001) (Fig. 2c ) and BM-ButFr [ F (3,28) = 48.28, P < 0.0001] (5–20 mg/kg; 0–8 h and 13–16 h, P < 0.001) (Fig. 2d ).

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