Iron Deposition Leads to Neuronal α-Synuclein Pathology by Inducing Autophagy Dysfunction.

The viability of neurons and SH-SY5Y cells exhibited a decreasing trend that was not significantly different ( p > 0.05) after incubation with 50 μM ferrous chloride.

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Following co-incubation with or without iron, rapamycin was observed a slight trend of reduction but did not significantly affect the α-synuclein levels in the control groups (Figures 4 A,C,D, p > 0.05); however, the upregulation of the α-synuclein levels induced by iron was ameliorated by the rapamycin treatment (Figures 4 A,C,D, p < 0.05).

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