Therefore, we performed a comprehensive correlation analysis using the following indices of treatment sensitivity and sought to obtain an overall trend: (i) the surviving fraction at all examined dose points, except 5 μM cisplatin (i.e., 2, 4, 6, and 8 Gy for X-rays, 1, 2, 3, and 4 Gy for carbon ions, and 0.2 and 1 μM for cisplatin).
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Mitotic catastrophe is a putative mechanism underlying the weak correlation between sensitivity to carbon ions and cisplatin.
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