Apelin receptor homodimer-oligomers revealed by single-molecule imaging and novel G protein-dependent signaling.

Sci Rep · 2017 · PMC5238433 · PMID 28091541

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a decreasing trendno p-value reported

12 , apelin-13 stimulation elicited a further increase in the HUVEC cell index (CI); however, co-stimulation with interference peptides corresponding to TMD1, which was demonstrated to disrupt APJ homodimers, led to a decreasing trend in the CI compared to that before treatment, suggesting disruption of APJ homodimers induced distinct cell responses after agonist stimulation.

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