A computational psychiatry approach identifies how alpha-2A noradrenergic agonist Guanfacine affects feature-based reinforcement learning in the macaque.

Analysis of the pattern of errors showed that there were similar amounts of premature fixation break errors prior to any stimulus change event with 0.075 mg/kg/24 h compared to control days, while higher doses were loosely linked with a statistical trend to higher proportions of premature fixation break errors (Wilcoxon rank sum test, p = 0.0518) ( Fig. 2E ).

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