Functional genomics reveals that tumors with activating phosphoinositide 3-kinase mutations are dependent on accelerated protein turnover.

Genes Dev · 2016 · PMC5238728 · PMID 28087713

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highly significantno p-value reported

In this comparison, depletion of KRAS itself scored as highly significant SL, as expected, while there was no enrichment of the PI3K.AKT.mTOR.Activation.Pathway among the SL genes ( Supplemental Tables S2, S6 ).

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