Vascular legacy: HOPE ADVANCEs to EMPA-REG and LEADER: A Surprising similarity.

Indian J Endocrinol Metab · 2017 · PMC5240071 · PMID 28217527

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highly significantno p-value reported

However, the highly significant benefits noted in the reduction of cardiovascular mortality and all-cause mortality did not extend to nonfatal stroke.

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borderline significantno p-value reported

In ADVANCE, active treatment led to a 21% reduction in all renal events with a borderline significant reduction in new or worsening nephropathy (RR 0.82, O < 0.055) and a significant reduction in the development of microalbuminuria (RR 0.81, P < 0.0001).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.