Integrative Analysis of Disease Signatures Shows Inflammation Disrupts Juvenile Experience-Dependent Cortical Plasticity.

To identify a focused subset of plasticity genes likely to be regulated by LPS (regardless of age or specific brain region) to test in vivo , we investigated a highly significant molecular match between the juvenile plasticity signature and an adult brain-derived LPS transcriptome ( GSE3253 ; rank #14, p = 7.9 × 10 −4 e ; empirical p value calculated using molecular match algorithm; Fig. 3a ; Table 3 ).

also in 132,142 other papers