Barely Significant
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A comprehensive evaluation of food fortification with folic acid for the primary prevention of neural tube defects.

BMC Pregnancy Childbirth · 2004 · PMC524178 · PMID 15450123

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highly significantno p-value reported
Rate of NTDs Our results show a highly significant drop in the rate of NTDs in Newfoundland, taking into account all identified affected pregnancies (live births, stillbirths and pregnancies terminated after a prenatal diagnosis of an NTD).

also in 132,142 other papers

an increasing trendno p-value reported
The 65% increase in the proportion of women taking vitamin supplements containing folic acid, from 17% in Phase I to 28% in Phase II, suggests that an increasing trend in folic acid supplementation may have played a role in the declining NTD rate in Newfoundland.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.