Modest overexpression of FOXO maintains cardiac proteostasis and ameliorates age-associated functional decline.

Aging Cell · 2017 · PMC5242305 · PMID 28090761

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highly significantno p-value reported

Specifically, between 1 and 7 weeks of age, control hearts experienced a highly significant decrease in cardiac output (100 ± 8 nL min −1 vs. 21 ± 2 nL min −1 ) (Fig. 2 B).

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