HLA-DRB1 Amino Acid Positions 11/13, 71, and 74 Are Associated With Inflammation Level, Disease Activity, and the Health Assessment Questionnaire Score in Patients With Inflammatory Polyarthritis.

We obtained an association for Val 11 with SJC that was almost significant (β coefficient of 0.25 [95% CI −0.00, 0.50], P = 0.051), but there was no significant association of ACPA status with SJC (β coefficient of 0.22 [95% CI −0.15, 0.59], P = 0.24), indicating that it is not possible to determine whether the nonsystemic effect of Val 11 is direct or mediated by ACPA status (green arrows in Figure 2 B).

also in 1,858 other papers

This pattern of association (highly significant P value before stratification, lack of significance after stratification) confirms that ACPA status is an important path variable in the etiology of clinical inflammation, but this analysis is inconclusive with regard to a minor independent effect of genetic factors on SJC (due to an underpowered study design).

also in 132,142 other papers