Association between lymphocyte expression of the apoptotic receptor Fas and pain in critically ill patients.

Furthermore, when multivariable mixed models were used to adjust for the presence of trauma, MODS severity and the dose of opioid analgesia and sedation, the association between pain ratings and Fas expression on cytotoxic T cells remained significant; however, the association with Fas expression on B cells exhibited a nonsignificant trend for positive association ( Table 2B ).

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When mixed linear models for the association between pain ratings and Fas expression were adjusted for the levels of ACTH, SP, and cortisol, simultaneously, the association of pain with Fas expression on B cells and cytotoxic T cells remained borderline significant ( Table 4C ); however, adjustment for 1 neuropeptide at the time did not accentuate the association between pain and Fas expression (results not shown).

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