ASXL1 interacts with the cohesin complex to maintain chromatid separation and gene expression for normal hematopoiesis.

The matches between these motifs and the known CTCF DNA binding motif were also highly significant, measured against the likelihood of the same matches by random sequences, with all significant FDR-adjusted P values for SMC1A in WT cells (4.12 × 10 − 13 ), RAD21 in WT cells (1.35 × 10 − 10 ), SMC1A in Asxl1 −/− cells (2.05 × 10 − 13 ), and RAD21 in Asxl1 −/− cells (2.64 × 10 − 9 ).

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