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Drug concentrations in the serum and cerebrospinal fluid of patients treated with norvancomycin after craniotomy.

Eur J Clin Microbiol Infect Dis · 2017 · PMC5253146 · PMID 27738856

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a decreasing trendno p-value reported
However, the drug concentration in the CSF tended to present a decreasing trend with time, which might indicate that the permeability of the drug had declined with gradual repair of the BBB.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.