Thermal activation of 'allosteric-like' large-scale motions in a eukaryotic Lactate Dehydrogenase.

Since we measured protein solutions at a concentration where protein-protein interactions may be significant, we calculated the single-protein diffusion coefficient in the infinite dilution limit D 0 ( Q ) from the effective diffusion D eff ( Q ) of Eq. 2 , by considering concentration-dependent inter-protein interactions and solvent-mediated interactions 50 : where H(Q ) is the hydrodynamic function representing Q -dependent hydrodynamic interparticle interactions mediated by the solvent, while the structure factor S(Q ) describes the direct inter-protein interactions.

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