Identification of a Putative Quantitative Trait Gene for Resistance to Obesity in Mice Using Transcriptome Analysis and Causal Inference Tests.

Quantitative complementation tests using SM/J and LG/J mice revealed that the Capn10 (calpain-10) gene is a QTG for Adip1 , an obesity QTL identified in a set of recombinant inbred strains between SM/J and LG/J, because highly significant interaction effects between Capn10 knockout and Adip1 genotypes were obtained for body weight, weights of fat pads, liver and heart, and serum leptin level [ 34 ].

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