Effects of cell type and configuration on anabolic and catabolic activity in 3D co-culture of mesenchymal stem cells and nucleus pulposus cells.

Collagen 2A1 expression decreased significantly in NPC‐only and co‐culture groups ( p < 0.05), while aggrecan expression decreased significantly in the NPC‐only group and showed a decreasing trend in the co‐culture group ( p < 0.05 prior to a multiple hypothesis correction).

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