In the whole cohort, the greatest loss of GFR was seen in patients with DSR at time point 2 ( Figure 2 a) and approximately 65% of patients with DSR at this time point appeared in the “deteriorating subgroup”; these relationships just failed to reach statistical significance.
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Graft dysfunction in chronic antibody-mediated rejection correlates with B-cell-dependent indirect antidonor alloresponses and autocrine regulation of interferon-γ production by Th1 cells.
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