Anti-proliferative activity of the NPM1 interacting natural product avrainvillamide in acute myeloid leukemia.

Significance were still observed after including two additional normal karyotype AML patient samples with FLT3–ITD and NPM1 wt and cells with FLT3–ITD mutations showed a distinct trend toward significance ( Figures 2g ; P =0.073) suggesting an AVA-sensitizing role for FLT3–ITD mutations. p53 sensitizes AML cells toward AVA treatment As NPM1 influences the activity and stability of the p53 protein 5 and given the association between TP53 mutations, p53 protein expression level, isoform profile and long-term survival in AML patients, 32 , 33 , 34 we examined the connection between AVA and p53.

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