Integrated genome-wide analysis of expression quantitative trait loci aids interpretation of genomic association studies.

For example, Cluster 51 targets the expression of 141 genes (Additional file 1 : Tables S6 and S7) including 13 genes ( PPM1A , TSPAN5 , APP , PIM1 , COPS2 , CSDE1 , WDTC1 , AP2A1 , CARM1 , FURIN , EPB49 , FAM134A , and SH3BGRL2 ) known [ 26 ] to be targets of a small set of miRNAs (miR-15A, miR-16, miR-15B, miR-195, miR-424, miR-497), a highly significant enrichment (FDR < 0.0001).

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Only a barely significant, twofold excess of lead trans- eQTLs were found with low RegulomeDB scores, suggesting that at most a modest fraction of trans- eQTLs are acting at known regulatory sites.

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