a nonsignificant trendP =0.171
There was a nonsignificant trend toward better outcomes after alteplase versus control among patients with obstructed (OR, 1.86; 95% CI, 0.76–4.53; P =0.171) versus patent (OR, 0.72; 95% CI, 0.42–1.25; P =0.241) arteries on the IST-3 angiography score, P =0.075 for interaction (Figures 1 and 2 ).