Barely Significant
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Nicotine as therapy.

PLoS Biol · 2004 · PMC526783 · PMID 15547644

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highly significantno p-value reported
Despite the small sample size, Flood says, the results were highly significant. “As far as I know this is the first clinical study to use nicotine for analgesia, and it was much more successful than I ever would have imagined.” “The nice thing about nicotine and drugs like nicotine is that they have opposite side effects to anesthetics.

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