Clinical Significance of Programmed Death Ligand‑1 and Intra-Tumoral CD8+ T Lymphocytes in Ovarian Carcinosarcoma.

On the contrary, our study revealed the negative effect of mesenchymal PD-L1 expression on survival, which was in line with the findings of Shen et al.[ 26 ] who also demonstrated a slight trend for poorer overall survival in osteosarcoma patients with high PD-L1 expression.

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Our results, showing a positive trend between intraepithelial PD-L1 expression and outcome, align with a recent study (Esfahani et al.[ 18 ]) which assessed the expression of PD-L1 in high grade serous ovarian cancer (HGSOC).They also confirmed the significant positive prognostic impact of PD-1 and PD-L1 mRNA expression.

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