HERV-K activation is strictly required to sustain CD133+ melanoma cells with stemness features.

Throughout the subsequent passages, the melanospheres forming efficiency of TVM-A12-CD133 + cells was significantly higher than the parental TVM-A12 cells (second passage p = 0.004, third passage p = 0.012), and only TVM-A12-CD133 + cells were able to achieve a highly significant increment in the number of melanospheres between the first and third passage ( p < 0.001).

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