Linker flexibility of IVS3-S4 loops modulates voltage-dependent activation of L-type Ca²⁺ channels.

Moreover, gradual changes of V 1/2 can be observed from both groups of α 1D E32 1F and α 1D E29 1S channels, indicating an apparent trend of V 1/2 modulations in accordance to the number of glycines ( Fig. 2C ).

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